Neen, the groundbreaking study on opioid effectiveness was given at the Toronto Addiction Conference by Dr Avram Goldstein in 1985. Dr Goldstein published irrefutable evidence that morphine is a hormone made in everyone's adrenal glands. Hundreds of studies since, bear this out, and explain multiple otherwise baffling facts about human biological clocks. Pre-employment drug screens look for acetylmorphine, which occurs in heroin, but do not test for morphine, because no one could pass!
The opioid denialists are today's Flat Earthers. A substance n
Nice commentary Neen. A very big problem with research in chronic pain is that there’s no distinction between study participants who have identified or no identified pathology. Without that granularity the averages appear to show nil benefit - in other words the studies are confounded. It’s fairly clear that where there is inadequate explanatory pathology for the pain, no pharmaceutical or combination has been found to achieve results superior to placebo (where placebo represents regression to the mean, false attribution, etc). However opioids are significantly effective when pathology is present. So if the patient experiences pain relief and improved function on opioids, we simply must believe them. We can’t have zealots interfering in patient care, particularly when the studies and reports they’re relying on are so flawed, and even fraudulent.
All of this opioid denialism flies in the face of Avram Goldstein's seminal 1985 paper showing that morphine is produced in the human adrenal glands. Literally hundreds of peer-reviewed studies prove that morphine is essential for metabolic regulation and erythrocyte function.
There are no morphine-free living people against whom to compare any of the studies on addiction. Everybody is normally exposed to this substance because like insulin, it is s hormone essential to life. So opiate addiction needs to be understood as not curable by removing the supply.
Here's a summary of all the work I could find in this subject. I published it on Academia.edu and hotlinked it on Twitter.
Neen, the groundbreaking study on opioid effectiveness was given at the Toronto Addiction Conference by Dr Avram Goldstein in 1985. Dr Goldstein published irrefutable evidence that morphine is a hormone made in everyone's adrenal glands. Hundreds of studies since, bear this out, and explain multiple otherwise baffling facts about human biological clocks. Pre-employment drug screens look for acetylmorphine, which occurs in heroin, but do not test for morphine, because no one could pass!
The opioid denialists are today's Flat Earthers. A substance n
Nice commentary Neen. A very big problem with research in chronic pain is that there’s no distinction between study participants who have identified or no identified pathology. Without that granularity the averages appear to show nil benefit - in other words the studies are confounded. It’s fairly clear that where there is inadequate explanatory pathology for the pain, no pharmaceutical or combination has been found to achieve results superior to placebo (where placebo represents regression to the mean, false attribution, etc). However opioids are significantly effective when pathology is present. So if the patient experiences pain relief and improved function on opioids, we simply must believe them. We can’t have zealots interfering in patient care, particularly when the studies and reports they’re relying on are so flawed, and even fraudulent.
All of this opioid denialism flies in the face of Avram Goldstein's seminal 1985 paper showing that morphine is produced in the human adrenal glands. Literally hundreds of peer-reviewed studies prove that morphine is essential for metabolic regulation and erythrocyte function.
There are no morphine-free living people against whom to compare any of the studies on addiction. Everybody is normally exposed to this substance because like insulin, it is s hormone essential to life. So opiate addiction needs to be understood as not curable by removing the supply.
Here's a summary of all the work I could find in this subject. I published it on Academia.edu and hotlinked it on Twitter.
http://t.co/pzVCtYWkeu